LADMER SYSTEM Lecture By: Abdul Mannan Definition of. Biopharmaceutics Biopharmaceutics is a major branch of the pharmaceutical sciences concerned. ·Chapter 2 -The LADMER system is a way of understanding what goes on in the body when any compound that has an effect on the body is administered or. Study Flashcards On LADMER System and Dissolution principles at Quickly memorize the terms, phrases and much more. makes it easy.
|Published (Last):||2 February 2011|
|PDF File Size:||2.17 Mb|
|ePub File Size:||3.29 Mb|
|Price:||Free* [*Free Regsitration Required]|
We think you have liked this presentation. If you wish to download it, please recommend it to your friends in any social system. Share buttons are a little bit lower. Published by Ezra Rose Modified over 3 years ago.
wystem If two products are said to be bioequivalent it means that they would be expected to be, for all intents and purposes, the same Non-equivalence Aldmer equality of therapeutic action of the same medicines in identical dozes and medicinal forms prepared by different manufacturers or the same factory, but different series Effective substance Biologically active part of medicine taking responsibility for its therapeutic ysstem Efficiency The production of the desired effects or results with minimum waste of time, effort, or skill Active ingredient That which enters into a compound, or is a component part of any combination or mixture; an element; a constituent.
Relative availability The quantity of medicinal substances in the biological liquid, which is released from the researched medicinal form, expressed as a Percentage, in comparison with Absolute bioavailability or with the standard medicinal form.
Dosage The determination and regulation of the size, frequency and number of doses Absorption The movement of a substance, wystem as a liquid or solute, across a cell membrane by means of diffusion or osmosis The constant for a drug administered by a route other than the intravenous.
The rate of absorption of a drug absorbed from its site of application according to first-order kinetics. A value describing systrm much drug is absorbed per unit of time Absorption rate constant ka.
The most common method of estimating AUC is to use the trapezoidal rule where the concentration-time curve is considered as a series of trapezoids and estimate zystem total area of all the trapezoids Area under curve AUC Clearance Cl Is a function of the blood flow rate Q to these organs.
It depends on the intrinsic ability of the organs such as the liver and kidneys to metabolize or excrete. It is evaluated from the PK data as shown in following: These factors include the route of administration; the dosage form; the liberation rate of the drug from the dosage form; dissolution; penetration and permeation of the drug through eystem its distribution within the body fluids and tissues; the type, amount and rate of biotransformation; and recycling processes and elimination.
In addition to these factors, pharmacogenetics and certain pathophysiological conditions also affect the above process. The entire process can be described as laxmer LADMER liberation, absorption, distribution, metabolism, elimination and response system showing that liberation, absorption, distribution, metabolism lwdmer elimination are involved to elicit the response.
One can subdivided this approach according to the scheme shown in fig. Efficiency of medicinal substances releasing is in direct dependence on pharmaceutical factors and their sytem use for advancement of active substances by following chart: Clinical practice showed that medicines having the same active substances in an identical dose, but produced.
Pharmacokinetics and biopharmaceutics – [email protected]
Objectives At the end of this sessions students should be able to: List and larmer common routes of drug administration. What the body does to the drug? Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform.
My presentations Profile Feedback Log out. Auth with social network: Registration Forgot your password?